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TITLE: The Sigma-1 receptor agonist PRE084 improves cardiopulmonary function and remodelling in an experimental model of pulmonary arterial hypertension Full Text
AUTHORS: Marta Villegas-Esguevillas; Bianca Barreira; Ana Hernández-García; Rui Adão ; Daniel Morales-Cano; María Sancho; Jorge Navarro-Dorado; Elena González-Lozano; Jesús Ruiz-Cabello; Francisco Pérez-Vizcaino; Belén Climent; Angel Cogolludo;
PUBLISHED: 2026, SOURCE: Biomedicine & Pharmacotherapy, VOLUME: 196

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TITLE: Combination of Orai1 inhibitor CM5480 with specific therapy mitigates pulmonary hypertension and its cardiac dysfunction
AUTHORS: Willer, Anais Saint Martin; Ruffenach, Gregoire; Masson, Bastien; El jekmek, Kristelle; Boet, Angele; Adao, Rui ; Gourmelon, Mathieu; Beauvais, Antoine; Sabourin, Jessica; Dutheil, Mary; Ghigna, Maria Rosa; Tesson, Laurent; Menoret, Severine; Anegon, Ignacio; Bauer, Fabrice; de Montpreville, Vincent; Hebbar, Sudarshan; Bras Silva, Carmen ; Stauderman, Kenneth; Humbert, Marc; Mercier, Olaf; Montani, David; Capuano, Veronique; Antigny, Fabrice; ...More
PUBLISHED: 2025, SOURCE: JCI INSIGHT, VOLUME: 10, ISSUE: 21

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TITLE: Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factors in 204 Countries and Territories, 1990-2023 Full Text
AUTHORS: Benjamin A Stark; Nicole K DeCleene; Emily C Desai; Johnathan M Hsu; Catherine O Johnson; Laura Lara Castor; Kate E LeGrand; Prof Bhoomadevi A; Mohammad Amin Aalipour; Hasan Aalruz; Bedru J Abafita; Ukachukwu O Abaraogu; Mohammad Abavisani; Nasir Abbas; Madineh Abbasi; Mohammadreza Abbasian; Hedayat Abbastabar; Abdallah H A Abd Al Magied; Samar Abd ElHafeez; Prof Ahmed Abdelalim; Omar M Abdelfattah; Prof Reda Abdel Hameed; Mahmoud Abdelnabi; Prof Wael M Abdel Rahman; Parsa Abdi; Wakgari Mosisa Abdisa; Daba Abdissa; Arman Abdous; Mujahid Abdullah; Auwal Abdullahi; Kulmira Abdykerimova; Mesfin Abebe; Aidin Abedi; Armita Abedi; Asrat Agalu Abejew; Abhilash E.S.; Olugbenga Olusola Abiodun; Prof Olumide Abiodun; Rahim Abo Kasem; Richard Gyan Aboagye; Shady Abohashem; Hassan Abolhassani; Ulric Sena Abonie; Abdullahi Tunde Aborode; Nagah Mohamed Abourashed; Dmitry Abramov; Lucas Guimarães Abreu; Dariush Abtahi; Rana Kamal Abu Farha; Aminu Kende Kende Abubakar; Ibrahim Jatau Abubakar; Nermeen Abu Elala; Eman Abu Gharbieh; Hana J Abukhadijah; Salahdein Aburuz; Dina Abushanab; Anirudh Balakrishna Acharya; Apurba Acharya; Swetha Acharya; Meshack Achore; Ousman Adal; Lisa C Adams; Lawan Hassan Adamu; Rui Adão ; Isaac Yeboah Addo; Oladimeji Muritala Adebayo; Tajudeen Adesanmi Adebisi; David Adedia; Kamoru Ademola Adedokun; Oluwatobi E Adegbile; Oyelola A Adegboye; Nurudeen A Adegoke; Victor Adekanmbi; Olumide Thomas Adeleke; Charles Oluwaseun Adetunji; Olorunsola Israel Adeyomoye; Rishan Adha; Kishor Adhikari; Ripon Kumar Adhikary; Wirawan Adikusuma; Tanin Adl Parvar; Mohd Adnan; Qorinah Estiningtyas Sakilah Adnani; Prince Owusu Adoma; Leticia Akua Adzigbli; David Adzrago; Ahmed M Afifi; Habeeb Abiodun Afolabi; Fatemeh Afrashteh; Arya Afrooghe; Muhammad Sohail Afzal; Saira Afzal; Suneth Buddhika Agampodi; Dhiraj Motilal Agarwal; Gina Agarwal; Prerna Agarwal; Temesgen Anjulo Ageru; Navidha Aggarwal; Sepehr Aghajanian; César Agostinis Sobrinho; ...More
PUBLISHED: 2025, SOURCE: JACC-JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, VOLUME: 86, ISSUE: 22

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TITLE: Global, regional, and national burden of pulmonary arterial hypertension, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021
AUTHORS: Peter J Leary; Megan Lindstrom; Catherine O Johnson; Sophia Emmons Bell; Stuart Rich; Paul A Corris; Hilary M DuBrock; Corey E Ventetuolo; Yohannes Habtegiorgis Abate; Michael Abdelmasseh; Richard Gyan Aboagye; Hasan Abualruz; Eman Abu Gharbieh; Salahdein Aburuz; Lawan Hassan Adamu; Rui Adão ; Isaac Yeboah Addo; Rufus Adesoji Adedoyin; Juliana Bunmi Adetunji; Leticia Akua Adzigbli; Bright Opoku Ahinkorah; Firdos Ahmad; Amir Mahmoud Ahmadzade; Ayman Ahmed; Haroon Ahmed; Syed Anees Ahmed; Shiva Akhlaghi; Mohammed Ahmed Akkaif; Salah Al Awaidy; Samer O Alalalmeh; Almaza Albakri; Khalifah A Aldawsari; Wael Almahmeed; Najim Z Alshahrani; Awais Altaf; Hany Aly; Karem H Alzoubi; Walid Adnan Al Zyoud; Reza Amani; Ganiyu Adeniyi Amusa; Catalina Liliana Andrei; Saleha Anwar; Anayochukwu Edward Anyasodor; Aleksandr Y Aravkin; Demelash Areda; Haftu Asmerom Asmerom; Avinash Aujayeb; Ahmed Y Azzam; Abraham Samuel Babu; Sara Bagherieh; Ovidiu Constantin Baltatu; Hiba Jawdat Barqawi; Mohammad Mahdi Bastan; Kavita Batra; Nebiyou Simegnew Bayleyegn; Amir Hossein Behnoush; Jaideep Singh Bhalla; Sonu Bhaskar; Vivek Bhat; Saeid Bitaraf; Veera R Bitra; Archith Boloor; Dejana Braithwaite; Michael Brauer; Lemma N Bulto; Yasser Bustanji; Vijay Kumar Chattu; Gerald Chi; Fatemeh Chichagi; Bryan Chong; Rajiv Chowdhury; Zinhle Cindi; Natalia Cruz Martins; Sriharsha Dadana; Omid Dadras; Tukur Dahiru; Xiaochen Dai; Mohadese Dashtkoohi; Sean DeAngelo; Shayom Debopadhaya; Berecha Hundessa Demessa; Hardik Dineshbhai Desai; Vishal R Dhulipala; Michael J Diaz; Mengistie Diress; Thanh Chi Do; Thao Huynh Phuong Do; Khanh Duy Doan; Wendel Mombaque dos Santos; Rajkumar Prakashbhai Doshi; Robert Kokou Dowou; Arkadiusz Marian Dziedzic; Muhammed Elhadi; Farshid Etaee; Natalia Fabin; Adeniyi Francis Fagbamigbe; Pawan Sirwan Faris; Bikila Regassa Feyisa; Celia Fortuna Rodrigues; Aravind P Gandhi; ...More
PUBLISHED: 2025, SOURCE: LANCET RESPIRATORY MEDICINE, VOLUME: 13, ISSUE: 1

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TITLE: Pharmacological clearance of senescent cells reduces inflammation, endothelial damage and cardiac fibrosis in HFpEF Full Text
AUTHORS: Silva, Elsa D.; Tome, Ines; Vasques Novoa, Francisco; Conceicao, Gloria; Silva, Andreia; Barros, Antonio S. ; Mendes Ferreira, Pedro; Santos Ribeiro, Diana; Goncalves, Alexandre; Angelico Goncalves, Antonio; Adao, Rui ; Caetano, Carolina; Sousa, Daniel; Miranda Silva, Daniela; Juni, Rio P.; Tchkonia, Tamara; Kirkland, James L.; Caramelo, Francisco; Goncalves, Nadia; Sampaio Pinto, Vasco; Ribeiro, Joao S.; Boon, Reinier A.; Leite Moreira, Adelino ; Pitrez, Patricia; Pinto do O, Perpetua; Santos, Susana G.; Falcao Pires, Ines; Ferreira, Lino; Nascimento, Diana S.; ...More
PUBLISHED: 2025, SOURCE: CARDIOVASCULAR RESEARCH, VOLUME: 121, ISSUE: 15

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