ProfileOfResearchers

TITLE: Design, synthesis and biological evaluation of antiparasitic dinitroaniline-ether phospholipid hybrids
AUTHORS: Roussaki, Marina; Magoulas, George E.; Fotopoulou, Theano; Santarem, Nuno; Barrias, Emile; Pohner, Ina; Luelmo, Sara; Afroudakis, Pantelis; Georgikopoulou, Kalliopi; Nevado, Paloma Tejera; Eick, Julia; Bifeld, Eugenia; Corral, Maria J.; Jimenez Anton, Maria Dolores; Ellinger, Bernhard; Kuzikov, Maria; Fragiadaki, Irini; Scoulica, Effie; Gul, Sheraz; Clos, Joachim; Prousis, Kyriakos C.; Torrado, Juan J.; Alunda, Jose Maria; Wade, Rebecca C.; de Souza, Wanderley; da Silva, Anabela Cordeiro; Calogeropoulou, Theodora; ...More
PUBLISHED: 2023, SOURCE: BIOORGANIC CHEMISTRY, VOLUME: 138

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TITLE: Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1 Full Text
AUTHORS: Poehner, Ina; Quotadamo, Antonio; Panecka Hofman, Joanna; Luciani, Rosaria; Santucci, Matteo; Linciano, Pasquale; Landi, Giacomo; Di Pisa, Flavio; Dello Iacono, Lucia; Pozzi, Cecilia; Mangani, Stefano; Gul, Sheraz; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Santarem, Nuno; Cordeiro da Silva, Anabela; Costi, Maria P.; Venturelli, Alberto; Wade, Rebecca C.;
PUBLISHED: 2022, SOURCE: JOURNAL OF MEDICINAL CHEMISTRY

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TITLE: Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth
AUTHORS: Costantino, Luca; Ferrari, Stefania; Santucci, Matteo; Salo Ahen, Outi M. H.; Carosati, Emanuele; Franchini, Silvia; Lauriola, Angela; Pozzi, Cecilia; Trande, Matteo; Gozzi, Gaia; Saxena, Puneet; Cannazza, Giuseppe; Losi, Lorena; Cardinale, Daniela; Venturelli, Alberto; Quotadamo, Antonio; Linciano, Pasquale; Tagliazucchi, Lorenzo; Moschella, Maria Gaetana; Guerrini, Remo; Pacifico, Salvatore; Luciani, Rosaria; Genovese, Filippo; Henrich, Stefan; Alboni, Silvia; Santarem, Nuno; da Silva Cordeiro, Anabela ; Giovannetti, Elisa; Peters, Godefridus J.; Pinton, Paolo; Rimessi, Alessandro; Cruciani, Gabriele; Stroud, Robert M.; Wade, Rebecca C.; Mangani, Stefano; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola; ...More
PUBLISHED: 2022, SOURCE: ELIFE, VOLUME: 11

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TITLE: Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform
AUTHORS: Carolina B Moraes; Gesa Witt; Maria Kuzikov; Bernhard Ellinper; Theodora Calogeropoulou; Kyriakos C Prousis; Stefano Mangani; Flavio Di Pisa; Giacomo Landi; Lucia Dello Lacono; Cecilia Pozzi; Lucio H Freitas Junior; Bruno dos Santos Pascoalino; Claudia P Bertolacini; Birte Behrens; Oliver Keminer; Jennifer Leu; Markus Wolf; Jeanette Reinshagen; Anabela Cordeiro da Silva ; Nuno Santarem; Alberto Venturelli; Stephen Wrigley; Deepa Karunakaran; Bethlehem Kebede; Ina Poehner; Wolfgang Mueller; Joanna Panecka Hofman; Rebecca C Wade; Martina Fenske; Joachim Clos; Jose M Maria Alunda; Maria J Jesus Corral; Elisa Uliassi; Maria Laura Bolognesi; Pasquale Linciano; Antonio Quotadamo; Stefania Ferrari; Matteo Santucci; Chiara Borsari; Maria Paola Costi; Sheraz Gul; ...More
PUBLISHED: 2019, SOURCE: SLAS DISCOVERY, VOLUME: 24, ISSUE: 3

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TITLE: Estimation of Drug-Target Residence Times by tau-Random Acceleration Molecular Dynamics Simulations Full Text
AUTHORS: Daria B Kokh; Marta Amaral; Joerg Bomke; Ulrich Graedler; Djordje Musil; Hans Peter Buchstaller; Matthias K Dreyer; Matthias Frech; Maryse Lowinski; Francois Vallee; Marc Bianciotto; Alexey Rak; Rebecca C Wade;
PUBLISHED: 2018, SOURCE: JOURNAL OF CHEMICAL THEORY AND COMPUTATION, VOLUME: 14, ISSUE: 7

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TITLE: Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity Full Text
AUTHORS: Flavio Di Pisa; Giacomo Landi; Lucia Dello Iacono; Cecilia Pozzi; Chiara Borsari; Stefania Ferrari; Matteo Santucci; Nuno Santarem; Anabela Cordeiro da Silva ; Carolina B Moraes; Laura M Alcantara; Vanessa Fontana; Lucio H Freitas Junior; Sheraz Gul; Maria Kuzikov; Birte Behrens; Ina Poehner; Rebecca C Wade; Maria Paola Costi; Stefano Mangani;
PUBLISHED: 2017, SOURCE: MOLECULES, VOLUME: 22, ISSUE: 3

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TITLE: Protein conformational flexibility modulates kinetics and thermodynamics of drug binding
AUTHORS: Amaral, M; Kokh, DB; Bomke, J; Wegener, A; Buchstaller, HP; Eggenweiler, HM; Matias, P; Sirrenberg, C; Wade, RC; Frech, M;
PUBLISHED: 2017, SOURCE: NATURE COMMUNICATIONS, VOLUME: 8, ISSUE: 1

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TITLE: Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs Full Text
AUTHORS: Chiara Borsari; Rosaria Luciani; Cecilia Pozzi; Ina Poehner; Stefan Henrich; Matteo Trande; Anabela Cordeiro da Silva ; Nuno Santarem; Catarina Baptista; Annalisa Tait; Flavio Di Pisa; Lucia Dello Iacono; Giacomo Landi; Sheraz Gul; Markus Wolf; Maria Kuzikov; Bernhard Ellinger; Jeanette Reinshagen; Gesa Witt; Philip Gribbon; Manfred Kohler; Oliver Keminer; Birte Behrens; Luca Costantino; Paloma Tejera Nevado; Eugenia Bifeld; Julia Eick; Joachim Clos; Juan Torrado; Maria D Jimenez Anton; Maria J Corral; Jose M Ma Alunda; Federica Pellati; Rebecca C Wade; Stefania Ferrari; Stefano Mangani; Maria Paola Costi; ...More
PUBLISHED: 2016, SOURCE: JOURNAL OF MEDICINAL CHEMISTRY, VOLUME: 59, ISSUE: 16

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